Multiplex Detection of Antibody Landscapes to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/Influenza/Common Human Coronaviruses Following Vaccination or Infection With SARS-CoV-2 and InfluenzaArticle Published on 2022-10-032022-11-15 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory illness acute respiratory syndrome Adsorption analyzed antibody antibody immunity antibody landscape Antibody Response ARI Clinical presentations collected common human coronaviruses coronavirus coronavirus 2 cross-reactive antibody detection exhibited Human human coronavirus human coronaviruses in-depth analysis individual Infection Influenza influenza infection influenza vaccine influenza virus landscape Last multiplex multiplex detection. no interaction protective immunity public health threat representing respiratory respiratory infection response responses SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 vaccination Sensitivity and specificity sera serological evidence serum Spike protein vaccination Vaccine [DOI] 10.1093/cid/ciac472 PMC 바로가기
An intranasal ASO therapeutic targeting SARS-CoV-2SARS-CoV-2를 표적으로 하는 비강내 ASO 치료제Article Published on 2022-08-032022-09-11 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, 치료법, 치료제, [키워드] administration antibody immunity Antisense oligonucleotide ASO binding complement conserved coronavirus COVID-19 COVID-19 pandemic Daily decrease disrupt Efficacy effort evade help higher infectivity human cells identify in vitro in vivo infected individuals Inhaled intranasal leader sequence lung Lungs mice new SARS-CoV-2 Non-invasive nucleic acid Pandemics Prevent preventing infection Rapid reduce RNA SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant sequence severity of COVID-19 suppresse tested the SARS-CoV-2 therapeutic Therapeutic approach therapeutic strategy therapeutic targeting tide Transmission turn vaccination Vaccine variant Viral viral replication Viral RNA [DOI] 10.1038/s41467-022-32216-0 PMC 바로가기 [Article Type] Article
Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species병원성 코로나바이러스 종에 대한 다중 LNP-mRNA 백신 접종Article Published on 2022-08-022022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated adaptive animal models antibody antibody immunity Antibody Response antigen-specific antibody B cell coronavirus Coronavirus vaccines COVID-19 vaccine CP: Immunology cross-reactivity Delta develop Differential gene expression effective feasibility immune immune cells Immune profile immune response immunology increase in induce MERS-CoV mRNA mRNA vaccine multiplexed vaccination multispecies coronavirus vaccine offer pathogenic coronavirus profile responses responses against RNA sequencing SARS-CoV SARS-CoV-2 sequential vaccination significantly single-cell single-cell profiling systems immunology. Transcriptome triplex vaccination vaccination schedule vaccine candidate [DOI] 10.1016/j.celrep.2022.111160 PMC 바로가기 [Article Type] Article
Omicron infection enhances Delta antibody immunity in vaccinated personsOmicron 감염은 예방 접종을 받은 사람의 Delta 항체 면역을 향상시킵니다.Article Published on 2022-07-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] absolute levels acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody immunity B.1.617.2 Beta BNT162b2 breakthrough infections coronavirus cross-protection Delta develop dominant elicit ENhance enrolment focus Follow-up follow-up time geometric geometric mean Immunity individual Infection interquartile range Johnson & Johnson median moderate neutralization neutralization capacity neutralization test neutralizing immunity offer omicron other variants participant Participants Pfizer Protective reduction respiratory severe acute respiratory syndrome Coronavirus South Africa Symptom symptom onset titre vaccinated individual vaccinated individuals vaccination variant variants virus Virus neutralization viruses [DOI] 10.1038/s41586-022-04830-x PMC 바로가기 [Article Type] Article
The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopesSARS-CoV-2 Delta 변이체는 주로 클래스 1 및 2 항체 에피토프에 초점을 맞춘 항체 반응을 유도합니다Article Published on 2022-06-292022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition antibodies antibody Antibody binding antibody epitope antibody immunity Antibody Response Antibody responses antigenic Beta Beta variant binding class D614G Delta delta variant Effect elicit elicited epitope Epitopes exposure help Impact induce Infection infections K417N mRNA mRNA vaccine Mutation neutralization Neutralizing antibody response polyclonal polyclonal antibody RBD Receptor-binding domain reduce responses SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 variant SARS-CoV-2 variants specificity the RBD the receptor-binding domain vaccination Vaccinations Vaccine variant virus viruses [DOI] 10.1371/journal.ppat.1010592 PMC 바로가기 [Article Type] Article
Potent antibody immunity to SARS‐CoV‐2 variants elicited by a third dose of inactivated vaccine불활성화 백신의 세 번째 접종으로 유발된 SARS-CoV-2 변이체에 대한 강력한 항체 면역Letter to Editor Published on 2022-02-272022-09-10 Journal: Clinical and Translational Medicine [Category] MERS, 변종, 진단, [키워드] antibody immunity dose elicited Inactivated vaccine potent SARS‐CoV‐2 variant [DOI] 10.1002/ctm2.732 PMC 바로가기 [Article Type] Letter to Editor
Specific CD8 + TCR Repertoire Recognizing Conserved Antigens of SARS-CoV-2 in Unexposed Population: A Prerequisite for Broad-Spectrum CD8 + T Cell ImmunityArticle Published on 2021-09-282022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome adaptive analyzed antibody immunity Antigen Blood broad-spectrum adaptive immunity CD8 CD8+ T cell CDR3 clone Clustering Cohort complementary conserved coronavirus coronavirus disease COVID-19 cross-reactive effort epitope Epitopes Evidence healthy healthy donor help Immunity implementation implicated IMPROVE in vitro individuals membrane memory T cell MHC-I mononuclear cell Mutation naïve neutralization nucleocapsid PBMCs peptide peptides peripheral populations proportion Protein Proteins provide recognizing recovered patient repertoire SARS-CoV-2 selected Sequencing Specific stimulated T cell T cell receptor T cells TCR TCR repertoire TCR sequencing the healthy therapy translational Vaccine variant virus [DOI] 10.3390/vaccines9101093 PMC 바로가기 [Article Type] Article
Similar antibody responses against SARS-CoV-2 in HIV uninfected and infected individuals on antiretroviral therapy during the first South African infection wave남아프리카 공화국의 첫 번째 감염 물결 동안 항레트로바이러스 요법을 받은 HIV 감염되지 않은 개인과 감염된 개인에서 SARS-CoV-2에 대한 유사한 항체 반응Major Article Published on 2021-09-022022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] addition African age anti-SARS-CoV-2 IgM antibodies antibody antibody immunity Antibody Response Antibody titer Antiretroviral therapy ART B cell response binding characterized circulating Comorbidity comparable Complete convalescent plasma COVID-19 COVID-19 vaccine Diagnosis effective First wave flow cytometry Frequency groups HIV IgA IgA antibody IgG IgM in both groups infected individual Infection Infectious disease Live virus Loss magnitude natural infection neutralization Neutralization assay neutralization potency PLWH Population potency provide Result SARS-CoV-2 SARS-CoV-2 infected individual SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 receptor secreting cell seroconversion rates significantly South South Africa sub-Saharan Africa uninfected was determined with HIV [DOI] 10.1093/cid/ciab758 PMC 바로가기 [Article Type] Major Article
Antibody Mediated Immunity to SARS-CoV-2 and Human Coronaviruses: Multiplex Beads Assay and Volumetric Absorptive Microsampling to Generate Immune Repertoire CartographyImmunology Published on 2021-07-272022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] 229E addition Analysis anti-S and anti-N antibodies antibodies antibody antibody immunity Antibody Response bead can be used category caused coefficient Combination Concentration condition convalescent COVID-19 pandemic COVID-19 vaccine COVID-19 vaccine studies Critical cross-reactive cross-reactive antibody immunity detect Effect Evidence fingerstick blood highly pathogenic HKU1 Human human coronavirus human coronaviruses human coronaviruses (HCoVs) Humoral immunity IgA IgG IgM IgM antibody indicate log MDs Mediated MERS MONITOR mPlex-CoV assay multidimensional Multiplex assay NL63 nucleocapsid OC43 pandemic preexisting human coronavirus immunity Protein recipient recipients repertoire reported SARS-CoV-1 SARS-CoV-2 scaling analysis sensitivity separated specificity strain Variation volumetric volumetric absorptive micro-sampling (VAMS) Zoonotic coronavirus [DOI] 10.3389/fimmu.2021.696370 PMC 바로가기 [Article Type] Immunology
A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responsesSARS-CoV-2 백신 BNT162b2의 단일 용량은 Fc 매개 항체 효과기 기능 및 T 세포 반응을 유발합니다Article Published on 2021-07-142022-09-11 Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 진단, [키워드] ADCC Administered analyzed antibody antibody immunity binding domain BNT162b2 BNT162b2 mRNA vaccine CD4 cellular condition contributing to coronavirus correlation COVID-19 dose doses effective Efficacy elicit elicited Fc-mediated effector function Fc-mediated effector functions function health authorities highlight humoral humoral responses include individual infected individuals mechanism mRNA mRNA vaccine neutralization Neutralizing activity public health authority raising regimen SARS-CoV-2 single dose spike glycoproteins Support T cell T cell response T cell responses T helper the SARS-CoV-2 vaccinate Vaccine vaccine efficacy variants variants. while [DOI] 10.1016/j.chom.2021.06.001 PMC 바로가기 [Article Type] Article